Diabetic Kidney Disease Map

Parametric ODE Interaction Networks

25 DKD-relevant kidney cell types modelled as parametric ODEs (SBML Level 3). Click any cell to visualise its reaction graph and explore kinetic rate equations.

25
Cell Types
~480
ODE Reactions / Cell
~220
Molecular Species
SBML L3
File Format
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Showing 25 cell types

Tubular

Proximal Convoluted Tubule

Bulk reabsorption of filtered solutes

ODEd[X]/dt = ΣV(n)
Tubular

Thick Ascending Limb Cell

Countercurrent multiplier, NaCl reabsorption

ODEd[X]/dt = ΣV(n)
Tubular

Distal Convoluted Tubule

Fine-tunes electrolyte reabsorption

ODEd[X]/dt = ΣV(n)
Tubular

Connecting Tubule Cell

Ion transport bridge between DCT and collecting duct

ODEd[X]/dt = ΣV(n)
Tubular

Principal Cell

Water & sodium transport in collecting duct

ODEd[X]/dt = ΣV(n)
Tubular

Intercalated Cell A

Acid secretion & base reabsorption

ODEd[X]/dt = ΣV(n)
Tubular

Intercalated Cell B

Base secretion & acid reabsorption

ODEd[X]/dt = ΣV(n)
Tubular

Macula Densa

Tubuloglomerular feedback sensor

ODEd[X]/dt = ΣV(n)
Glomerular

Podocyte Cell

Slit diaphragm filtration — primary DKD target

ODEd[X]/dt = ΣV(n)
Glomerular

Parietal Cell

Bowman's capsule epithelium

ODEd[X]/dt = ΣV(n)
Glomerular

Glomerular Capillary Cell

Primary filtration barrier capillaries

ODEd[X]/dt = ΣV(n)
Glomerular

Mesangial Cell

Structural support & filtration regulation

ODEd[X]/dt = ΣV(n)
Vascular

Endothelial Cell

Lines blood vessels, regulates permeability

ODEd[X]/dt = ΣV(n)
Vascular

Vasa Recta Cell

Medullary blood supply, osmotic exchange

ODEd[X]/dt = ΣV(n)
Vascular

Pericyte Cell

Microvascular tone & angiogenesis control

ODEd[X]/dt = ΣV(n)
Vascular

Vascular Smooth Muscle Cell

Tone & contractility of renal vasculature

ODEd[X]/dt = ΣV(n)
Immune

B Cell

Humoral immunity & antibody production

ODEd[X]/dt = ΣV(n)
Immune

T Cell

Adaptive cellular immunity effectors

ODEd[X]/dt = ΣV(n)
Immune

Natural Killer T Cell

Innate-adaptive bridge lymphocytes

ODEd[X]/dt = ΣV(n)
Immune

Plasma Cell

Terminal B cell — antibody secretion

ODEd[X]/dt = ΣV(n)
Immune

M2 Macrophage

Anti-inflammatory & tissue repair signaling

ODEd[X]/dt = ΣV(n)
Immune

Monocyte Cell

Innate immune differentiation lineage

ODEd[X]/dt = ΣV(n)
Immune

Non-classical Monocyte Cell

Patrol monocytes, inflammatory signaling

ODEd[X]/dt = ΣV(n)
Stromal

Fibroblast Cell

ECM synthesis and tissue remodeling

ODEd[X]/dt = ΣV(n)
Combined

All Cells Combined

Full DKD atlas — all 24 cell type interactions merged

ODEd[X]/dt = ΣV(n)